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Offering Circular Supplement (To Base Offering Circular dated October 1, 2004) $493,454,654 Government National Mortgage Association GINNIE MAE® Guaranteed REMIC Pass-Through Securities and MX Securities Ginnie Mae REMIC Trust 2007-049 The Securities The Trust will issue the Classes of Securities listed on the front cover of this offering circular supplement. The Ginnie Mae Guaranty Ginnie  Mae  will  guarantee  the timely payment of principal and interest on the securities. The Gin- nie Mae Guaranty is backed by the full faith and credit of the United States of America. The Trust and its Assets The Trust will own (1) Ginnie Mae Certificates and (2) certain previously issued certificates. The securities may not be suit- able investments for you. You should consider carefully the risks of investing in them. See "Risk Factors" beginning on page S-8 which highlights some of these risks. The Sponsor and the Co-Sponsor will offer the securities from time to time in negotiated transactions at varying prices. We expect the closing date to be August 30, 2007. You should read the Base Offering Circular as well as this Supplement. The securities are exempt from re- gistration under the Securities Act of 1933 and are "exempted securi- ties"  under  the  Securities  Ex- change Act of 1934. Class of REMIC Securities Original Principal Balance(2) Interest Rate Principal Type(3) Interest Type(3) CUSIP Number Final Distribution Date(4) Security Group 1 BD(1)....................................   $  3,400,000 6.50% SUP FIX 38375L AA8 August 2037 BG(1).................................... 12,515,164 6.50 SUP FIX 38375L AB6 March 2036 BH(1)  .................................. 14,463,685 6.50 SUP FIX 38375L AC4   December 2036 BI(1) .................................... 8,880,000 (5) NTL (PAC III/AD)   FLT/IO/DLY   38375L AD2 August 2037 BN  ........................................ 10,418,415 6.00 SUP FIX 38375L AE0 August 2037 BS .......................................... 33,300,000 (5) PAC III/AD INV/DLY 38375L  AF7 August 2037 BW ........................................ 500,000 6.25 SUP FIX 38375L AG5   December 2036 BZ.......................................... 1,304 6.00 PAC III FIX/Z 38375L AH3 August 2037 CI(1) .................................... 2,833,333 (5) NTL (PAC III/AD)   FLT/IO/DLY   38375L  AJ9 August 2037 CS.......................................... 10,000,000 (5) PAC III/AD INV/DLY 38375L AK6 August 2037 FB .......................................... 18,500,000 (5) SUP FLT/DLY 38375L AL4 August 2037 FE(1) .................................... 20,681,518 (5) NTL (PAC I) FLT/IO/DLY   38375L AM2 August 2037 ND ........................................ 31,587,670 6.00 PAC I FIX 38375L AN0 January 2037 NF..........................................   163,504,580 (5) PAC I FLT 38375L  AP5   December 2035 NO(1) .................................. 34,063,454 0.00 PAC I PO 38375L AQ3    December 2035 NY(1) ..................................   163,504,580 (5) NTL (PAC I) INV/IO 38375L AR1   December 2035 OB(1).................................... 8,880,000 0.00 PAC III/AD PO 38375L  AS9 August 2037 OC(1)  .................................. 2,833,333 0.00 PAC III/AD PO 38375L AT7 August 2037 OD(1)  .................................. 283,333 0.00 SUP PO 38375L AU4 August 2037 OE(1).................................... 20,681,518 0.00 PAC I PO 38375L AV2 August 2037 OG(1) .................................. 1,042,930 0.00 SUP PO 38375L AW0 March 2036 OH(1) .................................. 1,226,140 0.00 SUP PO 38375L  DL1    December 2036 QB(1).................................... 14,469,367 5.00 PAC II FIX 38375L AX8 August 2037 QI(1) .................................... 2,411,561 6.00 NTL (PAC II) FIX/IO 38375L AY6 August 2037 SB .......................................... 3,083,333 (5) SUP INV/DLY 38375L AZ3 August 2037 SE(1) .................................... 20,681,518 (5) NTL (PAC I) INV/IO/DLY   38375L BA7 August 2037 Security Group 2 FA.......................................... 41,710,659 (5) SC/PT FLT 38375L  BB5   September 2036 LO(1).................................... 6,951,776 0.00 SC/PT PO 38375L  BC3   September 2036 SY(1).................................... 41,710,659 (5) NTL (SC/PT) INV/IO 38375L BD1   September 2036 Security Group 3 CA  ........................................ 3,500,000 5.50 SC/SEQ FIX 38375L  BE9   November 2032 CB.......................................... 3,000,000 5.50 SC/SEQ FIX 38375L  BF6   November 2032 CD  ........................................ 2,000,000 5.50 SC/SEQ FIX 38375L BG4   November 2032 CG  ........................................ 1,500,000 5.50 SC/SEQ FIX 38375L BH2   November 2032 Security Group 4 BP .......................................... 4,917,326 6.00 SC/SUP FIX 38375L BK5 August 2037 BT .......................................... 1,700,000 6.00 SC/SEQ FIX 38375L  BL3 August 2037 UI(1) .................................... 9,804,667 (5) NTL (SC/SCH) FLT/IO/DLY   38375L BM1 August 2037 UO(1) .................................. 9,804,667 0.00 SC/SCH PO 38375L  BJ8 August 2037 US.......................................... 33,616,000 (5) SC/SCH INV/DLY 38375L BN9 August 2037 Residual RR1  ...................................... 0 0.00 NPR NPR 38375L  BP4 August 2037 RR2  ...................................... 0 0.00 NPR NPR 38375L BQ2 August 2037 (1)  These Securities may be exchanged for MX Securities described in Schedule I. (2)  Subject to increase as described under "Increase in Size" in this Supplement. The amount shown for each Notional Class (indicated by "NTL" under Principal Type) is its original Class Notional Balance and does not represent principal that will be paid. (3)  As defined under "Class Types" in Appendix I to the Base Offering Circular. The type of Class with which the Class Notional Balance of each Notional Class will be reduced is indicated in parentheses. (4)  See "Yield, Maturity and Prepayment Considerations – Final Distribution Date" in this Supplement. (5)  See "Terms Sheet – Interest Rates" in this Supplement. Citi GARDNER RICH, LLC The date of this Offering Circular Supplement is August 23, 2007. B-11